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Further experience with regional radiofrequency hyperthermia and cytotoxic chemotherapy for unresectable hepatic neoplasia
Author(s) -
Moffat Frederick L.,
Gilas Tomas,
Calhoun Kevin,
Falk Michael,
Dalfen Richard,
Rotstein Lorne E.,
Makowka Leonard,
Howard Victoria,
Laing David,
Venturi David,
Langer Jacob C.,
Falk Judith A.,
Falk Rudolf E.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850315)55:6<1291::aid-cncr2820550623>3.0.co;2-g
Subject(s) - medicine , colorectal cancer , chemotherapy , hyperthermia , oncology , disease , gastroenterology , cancer , radiology
The authors report on 178 patients with unresectable hepatic tumors who have been treated with 1 to 25 (median, 6) courses of radiofrequency hyperthermia (RFHT) and chemotherapy. In 137 patients, the hepatic tumors consisted of metastases from colorectal adenocarcinomas. For patients who had no previous therapy and who had colorectal metastases with no extrahepatic disease, cumulative survival at 52 weeks' follow‐up was 80.5% and partial tumor regression was seen in 78.4%. Among the 69 patients who previously had conventional treatment for their hepatic disease, partial regression was seen in 43.5%. We are no longer monitoring tumor core temperature routinely, as the invasive methods currently in use yield irreproducible results; the risks to the patient cannot be justified in view of the questionable relevance of the data obtained. A prospective randomized study of systemic chemotherapy with or without RFHT in patients with colorectal hepatic metastases is in progress. Cancer 55:1291‐1295, 1985.