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Combined preoperative and postoperative radiation for bladder cancer. Results of RTOG/Jefferson study
Author(s) -
Mohiuddin Mohammed,
Kramer Simon,
Newall Joseph,
Parsons James,
Wiley Albert,
Strong George,
Mulholland S. Grant
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850301)55:5<963::aid-cncr2820550508>3.0.co;2-#
Subject(s) - medicine , stage (stratigraphy) , surgery , radiation therapy , cystectomy , bladder cancer , incidence (geometry) , pelvis , cancer , adjuvant radiotherapy , paleontology , physics , optics , biology
Ninety‐two patients with bladder cancer have been treated with combined pre‐ and postoperative radiation in a Radiation Oncology Study Group (RTOG) Phase I–II study and at Thomas Jefferson University Hospital. Patients with invasive bladder cancer were entered into the study and given lowdose preoperative radiation (500 rad) to the whole pelvis, either on the day of or the day before cystectomy. Following surgery, patients were pathologically staged. Patients with stage B1 (T2) (grade 3 or 4), stage B2 and C (T3) tumors were given 4500 rad in 5 weeks postoperative radiation. Follow‐up in the study ranges from a minimum of 24 months to 5 years, with a median of 36 months. Incidence of complications was 15% (14/92). The 4‐year actuarial survival (Kaplan‐Meier) by stage of disease is 68% for stage B1 (T2) (grade 3 or 4), 78% for stage B2, and 57% for stage C. These survival results appear to be better than those obtained with other approaches of adjuvant therapy and/or surgery in comparable histopathologically staged patients.