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Alveolar soft‐part sarcoma. A study of 13 typical examples and one with a histologically atypical component
Author(s) -
Evans Harry L.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850215)55:4<912::aid-cncr2820550434>3.0.co;2-g
Subject(s) - alveolar soft part sarcoma , pleomorphism (cytology) , pathology , medicine , sarcoma , soft tissue , nuclear atypia , neoplasm , immunohistochemistry
Thirteen cases of typical alveolar soft‐part sarcoma and one in which the tumor had a histologically atypical component are presented. The atypical zone in the latter case was characterized by increased nuclear hyperchromatism and pleomorphism, increased nuclear‐cytoplasmic ratio, decreased cytoplasmic eosinophilia and granularity, a less distinct “nesting” pattern, and more numerous mitotic figures. The tumors occurred almost entirely in the younger decades and involved a variety of soft tissue sites. Sex distribution was 1:1, and there was a slight left‐sided predominance in tumor location. Median survival of the patients with typical alveolar soft‐part sarcoma was 79 months (the patient with the atypical neoplasm died at 36 months). The major factor related to both survival and the likelihood of metastasis was tumor size.