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Thromboembolic complications associated with L‐asparaginase therapy. Etiologic role of low antithrombin III and plasminogen levels and therapeutic correction by fresh frozen plasma
Author(s) -
Kucuk Omer,
Kwaan Hau C.,
Gunnar William,
Vazquez Richard M.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850215)55:4<702::aid-cncr2820550405>3.0.co;2-n
Subject(s) - fresh frozen plasma , medicine , antithrombin , streptokinase , thrombosis , coagulopathy , fibrinogen , deep vein , surgery , asparaginase , heparin , lymphoblastic leukemia , leukemia , myocardial infarction , platelet
Abstract A case of an 18‐year‐old woman with acute lymphoblastic leukemia who developed L‐asparaginase‐associated stroke and subclavian vein thrombosis is presented. The latter was also associated with a Hickman central venous catheter. Thrombotic complications occurred when plasma levels of plasminogen and antithrombin III were still markedly reduced as a result of L‐asparaginase therapy, although the fibrinogen had recovered from its lower levels. The stroke was treated with fresh frozen plasma and the subclavian vein thrombosis was treated with streptokinase and fresh frozen plasma. L‐asparaginase and Hickman‐associated coagulopathy is reviewed and the treatment is discussed.