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Clinical significance of heat labile regan isoenzyme variant in Hodgkin's disease
Author(s) -
Shetty P. A.,
Damle S. R.,
Shahane A. D.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850201)55:3<605::aid-cncr2820550321>3.0.co;2-3
Subject(s) - medicine , disease , isozyme , alkaline phosphatase , chemotherapy , gastroenterology , clinical significance , endocrinology , physiology , pathology , enzyme , biology , biochemistry
The activity of a heat labile variant of Regan type alkaline phosphatase (HLRI) was studied in the serum of 38 histologically proved patients with Hodgkin's disease. The activity was also studied in 40 normal healthy adults matched for age and sex as control. HLRI was significantly elevated in patients with Hodgkin's disease in comparison with normal controls (1.12 ± 0.12 units/ml vs 0.09 ± 0.01 units/ml; P < 0.001). The mean values of the isoenzyme tended to increase progressively with increasing stages of disease, reflecting a significant linear trend ( P < 0.001). The serial measurement of this variant may serve as a useful parameter in assessing disease activity and response to chemotherapy.