Premium
Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy
Author(s) -
Pintado Tomas,
Ferro Maria Teresa,
Román Carlos San,
Mayayo Magdalena,
Larana Jose G.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850201)55:3<535::aid-cncr2820550311>3.0.co;2-4
Subject(s) - medicine , acute leukemia , chromosomal translocation , incidence (geometry) , cytogenetics , cytotoxic t cell , chemotherapy , leukemia , breakpoint , chromosome , cancer research , gastroenterology , biology , genetics , gene , physics , optics , in vitro
Three patients presenting with acute leukemic disorder and chromosome 3 rearrangement involving bands q21;q26 are reported, and the literature on chromosome 3q abnormalities is reviewed. All reported patients carrying a paracentric 3q inversion or a translocation 3;3 with breakpoints in q21;q26 had a myelodysplastic or acute leukemic disorder with a normal or elevated platelet count and lack of response to cytotoxic drug therapy. They showed an associated incidence of −7 or 7q− anomalies higher than de novo acute leukemia and appear to constitute a definite subgroup of the leukemic disorders with very poor prognosis. The majority of patients showing other chromosome 3 long arm rearrangements showed evidence of leukemic process, were in blastic crisis, or had been exposed to chemotherapy, exhibiting also a higher incidence of associated −5 or −7 cytogenetic abnormalities than is observed in patients not exposed to toxic agents.