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Acute myeloblastic leukemia and sarcoidosis. Implications for pathogenesis
Author(s) -
Reich Jerome M.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850115)55:2<366::aid-cncr2820550212>3.0.co;2-1
Subject(s) - medicine , sarcoidosis , acute myeloblastic leukemia , pathogenesis , leukemia , immunology , neutropenia , myeloid leukemia , dermatology , chemotherapy
A disorder characterized by anemia and neutropenia due to impaired bone marrow function and a multisystem noncaseating granulomatous (NCG) disorder typical of sarcoidosis, culminated in acute myeloblastic leukemia (AML) in a patient after 6 years of observation. Linkage between the leukemia and sarcoidosis is suggested by a precedent case report, by the statistical remoteness of a fortuitous concurrence, by numerous reported instances of regional or systemic NCG accompanying a variety of malignancies, and by evidence of AML immunogenicity. It appears possible that the sarcoidosis in this patient represented a tissue reaction to the AML.