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Treatment of advanced esthesioneuroblastoma with high‐dose chemotherapy and autologous bone marrow transplantation. A case report
Author(s) -
O'Conor G. Thomas,
Drake Charles R.,
Johns Michael E.,
Cail Wayne S.,
Winn H. Richard,
Niskanen Eero
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850115)55:2<347::aid-cncr2820550207>3.0.co;2-n
Subject(s) - medicine , mucositis , esthesioneuroblastoma , chemotherapy , asymptomatic , cyclophosphamide , surgery , vinblastine , radiation therapy , total body irradiation , bone marrow transplantation , doxorubicin , transplantation
A 46‐year‐old woman presented with an advanced unresectable esthesioneuroblastoma which failed to respond to radiation therapy and one course of chemotherapy. She underwent treatment with high‐dose chemotherapy (cyclophosphamide, doxorubicin, and vinblastine) followed by autologous bone marrow transplantation. The major toxicity from the regimen was severe oropharyngeal mucositis. A complete remission was achieved and the patient is free of disease and asymptomatic 3.5 years after treatment.