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Changes in distribution of hepatic blood flow induced by intra‐arterial infusion of angiotensin II in human hepatic cancer
Author(s) -
Sasaki Yo,
Imaoka Shingi,
Hasegawa Yoshihisa,
Nakano Shunnichi,
Ishikawa Osamu,
Ohigashi Hiroaki,
Taniguchi Kenzo,
Koyama Hiroki,
Iwanaga Takeshi,
Terasawa Toshio
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850115)55:2<311::aid-cncr2820550202>3.0.co;2-m
Subject(s) - medicine , blood pressure , blood flow , peripheral , chemotherapy , distribution (mathematics) , angiotensin ii , hepatic arterial infusion , mean arterial pressure , endocrinology , cancer , heart rate , metastasis , mathematical analysis , mathematics
Changes in the distribution of the hepatic blood flow induced by intra‐arterial infusion of angiotensin II (AT‐II) were studied in human hepatic cancers using extremely short‐lived radioisotope (RI) (krypton 81 m [ 81m Kr]; half‐life, 13 seconds). After the start of continuous infusion of AT‐II, the radioactivity of the tumor showed about a two‐fold increase, whereas that of the nontumor region decreased to about one half as much as the level before the infusion. Consequently, the mean ratio of the arterial blood flow in the tumor region to that in the nontumor region (T/N ratio) increased to 3.30 ( P < 0.001). The T/N ratio showed a peak before the peripheral blood pressure reached the maximum, and thereafter tended to decrease. Intra‐arterial infusion of AT‐II raised the T/N ratio more obviously than did intravenous infusion of the drug, with less rise in the peripheral blood pressure. It is believed that intra‐arterial infusion chemotherapy with local use of AT‐II enables better accessibility of chemotherapeutic drugs to tumors.