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Growth hormone‐producing pituitary adenoma with crystal‐like amyloid immunohistochemically positive for growth hormone
Author(s) -
Mori Hiroshi,
Mori Shintaro,
Saitoh Youichi,
Moriwaki Kaname,
Iida Sayomi,
Matsumoto Keishi
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850101)55:1<96::aid-cncr2820550116>3.0.co;2-2
Subject(s) - adenoma , pituitary adenoma , amyloid (mycology) , medicine , pathology , endocrinology
Growth hormone (GH)‐producing pituitary adenoma from a 50‐year‐old acromegalic female was studied histochemically, immunohistochemically and electron microscopically. The adenoma was characterized by numerous crystal‐like amyloid bodies of 5 to 40 μm in diameter. In the periphery of the crystal‐like amyloid, bundles of amyloid fibrils were closely associated with deep invaginations of adenoma cells. The adenoma cells had numerous vesicles and vacuoles filled with amyloid fibrils, some of which were continuous with extracellular space. The crystal‐like amyloids, as well as the adenoma cells, were immunohistochemically positive for GH. It might be possible that disorder of hydrolysis of “prohormone,” from which GH is elaborated, is responsible for the amyloid production, and that amyloid discharge is accompanied with immunoreactive GH.