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Renal failure and hemolytic anemia associated with mitomycin C. A case report
Author(s) -
Price Todd M.,
Murgo Anthony J.,
Keveney John J.,
MillerHardy Diane,
Kasprisin Duke O.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850101)55:1<51::aid-cncr2820550109>3.0.co;2-d
Subject(s) - microangiopathic hemolytic anemia , medicine , pathology , fibrin , renal biopsy , mitomycin c , lamina densa , anemia , hemolytic anemia , microangiopathy , glomerulosclerosis , biopsy , kidney , endocrinology , proteinuria , thrombotic thrombocytopenic purpura , surgery , immunology , diabetes mellitus , basement membrane , platelet
The authors report a case of renal failure and microangiopathic hemolytic anemia associated with the administration of mitomycin C in a 62‐year‐old man. Examination of the renal biopsy specimen revealed glomerular sclerosis and necrosis with interstitial fibrosis on light microscopy. Electron microscopic findings revealed deposits of fibrin within the glomeruli and interstitial tissue and separation of glomerular epithelial cells from the underlying lamina densa. Following plasma exchange, the hemolytic process improved, but renal failure persisted.