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Prognostic factors influencing relapse of squamous cell carcinoma of the maxillary sinus
Author(s) -
Kondo Makoto,
Ogawa Koichi,
Inuyama Yukio,
Yamashita Shoji,
Tominaga Shinichi,
Shigematsu Naoyuki,
Nishiguchi Iku,
Hashimoto Shozo
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850101)55:1<190::aid-cncr2820550130>3.0.co;2-2
Subject(s) - medicine , neck dissection , radiation therapy , basal cell , bleomycin , stage (stratigraphy) , chemotherapy , epidermoid carcinoma , oncology , maxillary sinus , dissection (medical) , surgery , carcinoma , paleontology , biology
In 95 surgically staged patients with squamous cell carcinoma of the maxillary sinus, multivariate regression analyses were employed to identify prognostic factors. Possible prognostic factors for local control were TNM stage and type of surgical procedures: T2 or T3 tumors and use of total maxillectomy showed better local control rates ( P < 0.01). High radiation doses of 40 Gy or more also seemed to be of prognostic significance: P < 0.2 for 40 to 60 Gy, and P < 0.1 for 60 Gy or more. The risk of cervical relapse increased when the cheek or alveolus was grossly involved ( P < 0.2). However, since cervical relapse frequently accompanied uncontrollable primary recurrence or distant spread, and since cervical relapse alone was frequently salvaged by radical neck dissection, prophylactic irradiation to the neck is not recommended. Sex, age, nodal state, addition of chemotherapy, total doses of bleomycin or 5‐fluorouracil (5‐FU), or intra‐arterial administration of chemotherapeutic agents did not appear to be of prognostic significance.