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Malignant teratoma in the brain. An immunohistochemical study
Author(s) -
Nakamura Yasuhiro,
Sato Tomohiko,
Nishimura Go,
Tanimura Akira,
Takahashi Yasuhiro,
Hachisuka Hiroshi,
Masaike Kozue,
Yanai Toyohide,
Hashimoto Hironobu
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850101)55:1<103::aid-cncr2820550117>3.0.co;2-k
Subject(s) - pathology , enolase , glial fibrillary acidic protein , neuroectoderm , immunohistochemistry , carcinoembryonic antigen , ependyma , cytokeratin , teratoma , germ cell tumors , medicine , biology , histogenesis , anatomy , embryonic stem cell , central nervous system , endocrinology , cancer , mesoderm , biochemistry , chemotherapy , gene
A case of intracranial malignant teratoma found in a 27‐year‐old man was reported. This unique tumor was found in the right frontal lobe separated from the pineal region and revealed various tissue components such as stratified squamous epithelium, glandular tissues, neuron, glia, ependyma, fibro‐muscular tissue, cartilage, bone, hemangiomatous lesion, malanin‐laden cells, and some germ cell components. An immunohistochemical study demonstrated the presence of S‐100 protein, glial fibrillary acidic protein (GFAP), neuron‐specific enolase (NSE), carcinoembryonic antigen (CEA), and Factor VIII in some tumorous components. In particular, the distribution of S‐100 protein in some germ cells suggested the possibility of the neuroectodermal origin of the germ cells or, alternatively, differentiation to the neuroectoderm.