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Adverse metabolic consequences of total parenteral nutrition
Author(s) -
Klein Gordon L.,
Rivera David
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850101)55:1+<305::aid-cncr2820551317>3.0.co;2-x
Subject(s) - medicine , parenteral nutrition , metabolic bone disease , etiology , micronutrient , intensive care medicine , osteomalacia , malnutrition , urea cycle , gastroenterology , pathology , vitamin d and neurology , osteoporosis , biochemistry , chemistry , arginine , amino acid
Recently described metabolic complications of total parenteral nutrition (TPN) are discussed. Included are descriptions of disorders affecting the hepatobiliary system and the musculoskeletal system. The effects of TPN on the hepatobiliary system include cholestatic hepatitis and cholelithiasis; the complications affecting the musculoskeletal system include acute polymyopathy and low‐turnover, osteoma‐lacic bone disease. With the exception of the acute polymyopathy, which is probably due to essential fatty acid deficiency, the other systemic disorders may have multiple etiologies. Also summarized are the relatively recent findings of iatrogenic micronutrient deficiencies, including chromium, selenium, and molybdenum. These trace element deficiencies appear to have multisystem manifestations. Recommendations for management are discussed.