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Histocompatibility antigens in small cell carcinoma of the lung
Author(s) -
Markman Maurie,
Braine Hayden G.,
Abeloff Martin D.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841215)54:12<2943::aid-cncr2820541221>3.0.co;2-#
Subject(s) - histocompatibility , medicine , human leukocyte antigen , population , immunology , antigen , allele , lung cancer , major histocompatibility complex , survival rate , biology , genetics , gene , environmental health
Fifty white patients with small cell carcinoma of the lung (SCCL) were typed for histocompatibility antigens (HLA) to assist in providing platelet support for intensive induction therapy. An analysis of the HLA types in this population was undertaken to determine if there was an influence of HLA type on this disease. Patients with the HLA‐Bw44 (HLA‐B12) allele were found to be significantly over‐represented in our patient population compared to a control population (52% versus 26%, P < 0.001). In addition, patients possessing the HLA‐A1 phenotype were found to have a significantly poorer 1‐year survival rate (15%) than individuals who did not possess this allele (60% 1‐year survival rate) ( P < 0.025). These findings will need to be confirmed by other groups working with large numbers of patients with SCCL.