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Progress toward therapeutic application of interferons, 1979–1983
Author(s) -
Borden Ernest C.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841201)54:2+<2770::aid-cncr2820541425>3.0.co;2-0
Subject(s) - medicine , immune system , disease , malignant cells , interferon , modalities , cell , cancer , cell growth , therapeutic modalities , malignant disease , function (biology) , viral replication , virus , immunology , treatment modality , cancer research , biology , microbiology and biotechnology , biochemistry , social science , sociology
Interferons differ chemically and biologically from other modalities of cancer treatment. They are proteins that inhibit viral replication, influence subcellular processes, slow cellular proliferation, affect cell differentiation, and modulate immune responses. These regulatory effects on cell function undoubtedly underlie the effects of interferons in malignant disease. As a result of efforts by academia, industry, governments, and organizations such as the American Cancer Society, significant progress has been made over the past 5 years in elucidating structure, improving production, and defining clinical applications of interferons for both virus and malignant disease.