Premium
Papillary adenocarcinoma of the male urethra: Case report and review of the literature
Author(s) -
Bostwick David G.,
Lo Richard,
Stamey Thomas A.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841201)54:11<2556::aid-cncr2820541142>3.0.co;2-7
Subject(s) - medicine , pathology , adenocarcinoma , immunoperoxidase , urethra , dysplasia , carcinoembryonic antigen , malignancy , prostatic urethra , prostate , papillary tumor , carcinosarcoma , prostatic acid phosphatase , carcinoma , urology , cancer , antibody , immunology , monoclonal antibody
Mucinous papillary adenocarcinoma of the bulbous urethra developed in a 40‐year‐old man with congenital stricture. The tumor appeared as a localized polypoid exophytic mass without evidence of submucosal invasion (Stage 0). The tumor was determined not to be of prostatic origin clinically and by absence of immunoperoxidase staining for prostatic acid phosphatase, prostate specific antigen, and carcinoembryonic antigen. Surgical resection of the urethra revealed extensive squamous and glandular metaplasia (urethritis glandularis) in association with the neoplasm. The mucosa displayed a spectrum of epithelial changes varying from dysplasia to carcinoma in situ , in confirmation of the urethral origin of the tumor. These observations emphasize the close association of metaplastic proliferative lesions and malignancy in the lower urinary tract.