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Superficial cerebral astrocytoma attached to dura: Report of six cases in infants
Author(s) -
Taratuto Ana Lía,
Monges Jorge,
Lylyk Pedro,
Leiguarda Ramón
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841201)54:11<2505::aid-cncr2820541132>3.0.co;2-g
Subject(s) - immunoperoxidase , pleomorphism (cytology) , pathology , glial fibrillary acidic protein , astrocytoma , medicine , anatomy , immunohistochemistry , temporal lobe , frontal lobe , glioma , epilepsy , cancer research , monoclonal antibody , psychiatry , antibody , immunology
Reported are six cases of meningocerebral astrocytomas attached to dura, involving the superficial cortex, in infants under 1 year of age. They represent 1.25% of 483 intracranial tumors in infancy studied at the Children's Hospital in the last 12 years. Five were located in the frontal lobes, with variable extension to the parietal or the parietotemporal regions, and one was located in the parietal lobe. They were all composed of a solid portion and one or more cysts, and they measured approximately 6 to 12 cm in diameter. They had spindle cells, some more plump, arranged in areas in a storiform pattern. Tumors were very rich in reticulin fibers, mimicking a mesenchymal tumor. There was very slight pleomorphism. Bizarre giant cells were not observed and lipidization was not a prominent feature. Immunoperoxidase technique was performed in all of them and showed glial fibrillary acidic protein (GFAP) in most of the tumor cells. We believe their origin is from subpial astrocytes. They probably represent a separate entity whose diagnosis cannot be accurately established without immunohistochemical techniques.