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Promyelocytic blast crisis of chronic myelocytic leukemia with both t(9;22) and t(15;17) in M3 cells
Author(s) -
Castaigne Sylvie,
Berger Roland,
Jolly Veronique,
Daniel Marie Therese,
Bernheim Alain,
Marty Michel,
Degos Laurent,
Flandrin Georges
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841201)54:11<2409::aid-cncr2820541117>3.0.co;2-v
Subject(s) - chromosomal translocation , acute promyelocytic leukemia , karyotype , medicine , leukemia , population , myelocytic leukemia , blast crisis , cancer research , immunology , chromosome , genetics , biology , cell culture , retinoic acid , environmental health , gene
A blast crisis with the features of promyelocytic leukemia (M3) occurred during the evolution of chronic myelocytic leukemia (CML) with the t(9;22) translocation. This rare form of transformation was confirmed by means of cytologic and electron microscopic examination. Cytogenetic studies showed two simultaneous translocations t(15;17) and t(9;22) in the promyelocytes. After intensive chemotherapy, a complete remission was obtained and only karyotypes with t(9;22) translocation were present. These data confirm the specificity of the t(15;17) translocation in malignant promyelocytic proliferation and provide evidence for a second genetic event in the genesis of blast crisis occurring in a committed cell belonging to the abnormal population defined by the Ph1 chromosome.