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Complications following postoperative combined radiation and chemotherapy in adenocarcinoma of the rectum and rectosigmoid: A randomized trial that failed
Author(s) -
Sparsø Bo Hempel,
von der Maase Hans,
Kristensen Dan,
Christiansen John,
Nielsen Svend Å. Damgaard,
Hebjørn Morten,
Andersen Bjørn
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841201)54:11<2363::aid-cncr2820541110>3.0.co;2-u
Subject(s) - medicine , rectum , randomized controlled trial , surgery , adenocarcinoma , methotrexate , radiation therapy , chemotherapy , adjuvant chemotherapy , adjuvant , cancer , breast cancer
A randomized multicenter trial was started to evaluate the effect of irradiation combined with 5‐fluorouracil and methotrexate on survival after surgery for rectal and rectosigmoidal carcinoma, Dukes' stages B and C. The trial was terminated prematurely after entrance of 34 patients due to frequent and serious complications. Three patients died as a direct consequence of the adjuvant treatment.