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Large cell carcinoma of the lung associated with marked eosinophilia. A case report
Author(s) -
Kodama Tetsuro,
Takada Kenichi,
Kameya Toru,
Shimosato Yukio,
Tsuchiya Ryosuke,
Okabe Tetsuro
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841115)54:10<2313::aid-cncr2820541044>3.0.co;2-i
Subject(s) - eosinophil , medicine , eosinophilia , pathology , bone marrow , lung , autopsy , carcinoma , immunology , asthma
A case of large cell carcinoma of the lung which produced eosinophil colony stimulating factor and eosinophil chemotactic factor was reported. A 52‐year‐old Japanese man with a tumor in the left upper lobe of the lung underwent left pneumonectomy. Marked eosinophilia persisted especially after recurrence, with a maximum peripheral leukocyte count of 161,000/mm 3 , of which 78% consisted of eosinophils. The patient died of pulmonary insufficiency 18 months after surgery. At autopsy, metastatic tumor tissues and almost all organs were markedly infiltrated with eosinophils, especially the spleen, and there was marked proliferation of eosinophils in the bone marrow. Eosinophil colony stimulating factor production by the transplanted tumor in a nude mouse was confirmed by use of a human bone marrow culture assay system. Eosinophil chemotactic factor production by metastatic tumor tissue also was proved by a modified microfilter technique.