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Prophylactic diazepam in prevention of contrast media‐associated seizures in glioma patients undergoing cerebral computed tomography
Author(s) -
Pagani John J.,
Hayman L. Anne,
Bigelow Robert H.,
Libshitz Herman I.,
Lepke Ronald A.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841115)54:10<2200::aid-cncr2820541022>3.0.co;2-2
Subject(s) - medicine , glioma , contrast (vision) , etiology , computed tomographic , incidence (geometry) , epilepsy , diazepam , anesthesia , computed tomography , surgery , psychiatry , physics , cancer research , artificial intelligence , computer science , optics
Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media‐associated seizures from 16% to 2% in a prospective, randomized series of glioma patients. Factors related to increased risk of contrast media‐associated seizures are (1) prior seizure history due to glioma and/or prior contrast media and (2) prior or concurrent brain antineoplastic therapy. Factors not related to an increased risk of contrast media‐associated seizures are (1) contrast media dosage, (2) type or grade of glioma, and (3) computerized tomographic apperance of the glioma. Therories regarding the etiology of contrast media‐associated seizures are discussed.