Premium
A case report of T‐Cell lymphoma with suppressor phenotype and helper function for immunoglobulin synthesis
Author(s) -
Oshimi Kazuo,
Aoyama Masako,
Ohtani Toshika,
Okawa Hiroji,
Yata Junichi,
Watanabe Shaw,
Mizoguchi Hideaki
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841101)54:9<2029::aid-cncr2820540941>3.0.co;2-l
Subject(s) - lymphoma , cytotoxic t cell , lymph node , immunology , medicine , antibody , suppressor , hypergammaglobulinemia , pokeweed mitogen , monoclonal antibody , t cell , b cell , biology , immune system , in vitro , cancer , concanavalin a , biochemistry
A patient with T‐cell lymphoma is presented. The morphologic features of a biopsied lymph node were consistent with adult T‐cell lymphoma with hypergammaglobulinemia, and most of the lymph node cells were reactive with monoclonal antibody OKT8, which detects suppressor/cytotoxic T lymphocytes. However, in a pokeweed mitogen‐driven test system in which the capability of T lymphocytes to help or suppress the differentiation of B lymphocytes is measured, the lymphoma cells induced immunoglobulin synthesis of B lymphocytes, thus providing helper function. As far as we know, this is the first report on T‐cell lymphoma having suppressor phenotype and helper function for immunoglobulin synthesis.