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Urinary cytodiagnostic abnormalities in 50 patients with non‐Hodgkin's lymphomas
Author(s) -
Cheson Bruce D.,
Schumann Janet L.,
Schumann G. Berry
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841101)54:9<1914::aid-cncr2820540923>3.0.co;2-7
Subject(s) - medicine , cytology , urine cytology , urinary system , lymphoma , pathology , urine , chemotherapy , kidney , stage (stratigraphy) , urology , paleontology , cystoscopy , biology
Abstract Urinary cytodiagnostic evaluation was performed on 50 consecutive patients with non‐Hodgkin's lymphomas. In 14 patients (28%) the urine sediment contained characteristic lymphoma cells. The groups with or without a positive urine cytology were comparable with respect to type of lymphoma, stage and course of disease, and recent treatment with chemotherapy. However, those with a positive urine cytology were more likely to have clinical evidence of kidney disease (43% vs 8%), although this was rarely attributed to disseminated lymphoma. In fact, in three patients, a positive urine cytology was the sole or presenting evidence for disseminated lymphoma. Although the groups with or without a positive cytology were similar with regard to physicochemical urinary findings, there were marked differences in the frequency of microscopic abnormalities. All patients with a positive cytology had evidence of renal parenchymal necrosis, renal tubular injury, or pathologic cast formation as compared with only 56% of those with a negative cytology. Thus, urinary cytodiagnostic evaluation may provide an important adjunct in the staging and evaluation of patients with malignant lymphomas.