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Does total parenteral nutrition (TPN) really promote tumor growth?. A morphometric study
Author(s) -
Hasegawa Junklchl,
Okada Aklra,
Nakao Kazuyasu,
Kawashima Yasunaru
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841015)54:8<1739::aid-cncr2820540845>3.0.co;2-j
Subject(s) - medicine , parenteral nutrition , body weight , cancer , zoology , nuclear medicine , biology
An experimental study was undertaken to evaluate the effects of total parenteral nutrition (TPN) on tumor growth in rats. Sato lung cancer was transplanted subcutaneously in male Donryu rats. Two weeks after inoculation, experimental animals were divided into three groups: Group I (5% Gk Group II (21% G, 4% A.A; TPN) received intravenous infusion through cervical vein; Group III rats were maintained on a regular diet. All of the animals were killed on the eighth day. There was a significant increase in tumor volume and tumor weight in both G‐II (7.3 ± 3.9 cm 3 , 8.7 ± 6.3 g) and G‐III (7.4 ± 4.6 cm 3 , 9.7 ± 5.4 g), as compared with G‐I (3.3 ± 1.4 cm 3 , 3.7 ±1.9 g). In morphometric studies, an average area of tumor cell in G‐II was 267 ±172 μm 2 , being significantly larger than in G‐I (195 ± 95 μm 2 ) or G‐III (185 ± 93 μm 2 ). The nuclear diameter of tumor cell was 9.9 ± 2.2 μm in G‐II, 9.2 ± 1.9 μm in G‐III, and 8.5 ± 1.5 μm in G‐I, respectively. Total water balance throughout the experimental period was +84.0 ± 14.5 ml/100 g BW in G‐II, +86.3 ± 8.2 mL/100 g BW in G‐III, and +44.8 ± 22.5 ml/100 g body weight in G‐I, respectively. Increased tumor volume and tumor weight found in G‐II may not be due to hyperplasia of each tumor cell, but rather due possibly to water retention in tumor tissue.