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The subrenal capsule assay in mice. Prediction of rat tumor sensitivity to chemotherapy
Author(s) -
Mäenpää Juhani,
Grönroos Matti,
Leppänen Milla,
Kangas Lauri
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841015)54:8<1530::aid-cncr2820540810>3.0.co;2-x
Subject(s) - chemotherapy , medicine , proto oncogene tyrosine protein kinase src , capsule , predictive value , assay sensitivity , oncology , pathology , cancer research , biology , receptor , botany , alternative medicine
The predictive value of the subrenal capsule (SRC) assay for cancer chemotherapy was tested in five rat tumors. Tumor‐bearing rats were used as controls. In order to simulate clinical chemotherapy, different dose regimens and drug combinations were used. All five tumors were evaluable in the SRC assay. Taking into account cytotoxic drugs, 86% compatibility was obtained between the SRC assay and the rat model. Antitumor effect of three antiestrogenic compounds could not be predicted by the SRC assay. It is concluded that the SRC assay can be expected to have predictive value in the assessment of tumor sensitivity to single and combination chemotherapy based on experimental animal models.