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Effects of lntravesical instillation of antitumor chemotherapeutic agents on bladder carcinogenesis in rats treated with N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine
Author(s) -
Ohtani Mikinobu,
Fukushima Shojl,
Okamura Takehiko,
Sakata Takao,
Ito Nobuyuki,
Koiso Kenkichl,
Niijima Tadao
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19841015)54:8<1525::aid-cncr2820540809>3.0.co;2-u
Subject(s) - nitrosamine , medicine , urology , doxorubicin , mitomycin c , hyperplasia , urinary bladder , bladder neoplasm , bladder cancer , carcinogen , pathology , chemotherapy , cancer , surgery , chemistry , organic chemistry
The effects of intravesical instillation of Adriamycin (doxorubicin) (ADR), and mitomycin C (MMC), as inhibitors of development of rat bladder tumors, were examined in rats treated with N‐butyl‐N‐(4‐hydroxybuty1)nitrosamine (BBN). Intravesical instillation of ADR or MMC once a week for 12 weeks into rats pretreated with BBN for 4 weeks markedly enhanced development of bladder tumors. That is, one week after the end of intravesical instillation of these compounds the incidence of papillary or nodular hyperplasias, namely preneoplastic lesions, was significantly increased, and at the end of the experiment the incidence of not only papillary or nodular hyperplasias but also of papillomas and cancers was significantly increased. These results indicate that the intravesical instillation of ADR or MMC promotes two‐stage bladder carcinogenesis in rats.