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Remission and exacerbation of tumor‐related nephrotic syndrome with treatment of the neoplasm
Author(s) -
Robinson Warren L.,
Mitas John A.,
Haerr Robert W.,
Cohen Irving M.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840915)54:6<1082::aid-cncr2820540625>3.0.co;2-3
Subject(s) - medicine , nephrotic syndrome , exacerbation , renal biopsy , glomerulonephritis , gastroenterology , nephritic syndrome , biopsy , pathology , kidney
A 61‐year‐old man presented with nephrotic syndrome in March 1978. Renal biopsy revealed mesangial and endocapillary proliferation with no underlying cause found. One year later, evaluation of back pain resulted in the finding of undifferentiated adenocarcinoma with compression fracture of the T‐11 vertebra. Local irradiation relieved the pain and ameliorated the nephrotic syndrome. In 1981 the nephrotic syndrome recurred. Evaluation revealed metastases to the right pelvis and to the brain without an identifiable primary lesion. Irradiation of these lesions reduced protein excretion to 50 to 150 mg/day. A gastric carcinoma was later found. Exacerbation of nephrotic syndrome may herald exacerbation of tumor activity as occurs in Hodgkin's disease. Survival with tumor‐related nephrotic syndrome is not invariably poor, and treatment of metastases may be worthwhile in similar patients in whom only partial tumor reduction is possible.