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Prostatic adenocarcinoma with carcinoidal features producing adrenocorticotropic syndrome. Immunohistochemical study and review of the literature
Author(s) -
Ghali Violette S.,
Garcia Roger L.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840915)54:6<1043::aid-cncr2820540619>3.0.co;2-u
Subject(s) - immunohistochemistry , medicine , pathology , adenocarcinoma , neural crest , adrenocorticotropic hormone , autopsy , cancer , biology , hormone , microbiology and biotechnology , embryo
An autopsy case of disseminated, miliary‐type, composite adenocarcinoma and carcinoid tumor associated with adrenocorticotropic syndrome is discussed. Prostatic origin and functional activity were demonstrated by immunohistochemical techniques. Of interest in this case is that the tumor had the characteristics of amine precursor uptake and decarboxylation (APUD) cells and also kept the antigenicity of its prostatic origin. The APUD system perhaps should be considered as one form of functional differentiation of cells of different origin rather than an exclusive derivative of the neural crest.