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Conference summary. Dose—response relationship in clinical oncology
Author(s) -
Brade Wolfgang P.,
Freireich Emil J,
Goldin Abraham
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840915)54:1+<1226::aid-cncr2820541321>3.0.co;2-a
Subject(s) - medicine , clinical oncology , oncology , medical physics , cancer
The dose—response relationship can be understood as an input—output process. The input is determined by the drug, its amount, manner, and interval of application, and can be modified by drug formulation and combination. The output can be defined as cure, increase of survival, relapse‐free survival, complete, and partial remission. The black box between input and output contains host factors, tumor factors, and drug factors which finally lead to the therapeutic and toxic response.