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Late effects of radiotherapy on patients with cerebellar medulloblastoma
Author(s) -
Silverman Craig L.,
Palkes Helen,
Talent Barbara,
Kovnar Edward,
Clouse John W.,
Thomas Patrick R. M.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840901)54:5<825::aid-cncr2820540511>3.0.co;2-l
Subject(s) - medulloblastoma , medicine , intelligence quotient , neuropsychology , radiation therapy , pediatrics , wechsler adult intelligence scale , surgery , cognition , psychiatry , pathology
Nine long‐term survivors of cerebellar medulloblastoma treated with surgery and irradiation were retrospectively examined with a complete battery of neuropsychological tests and the results compared with their nonirradiated siblings. Significant decreased scores were found in the full‐scale intelligence quotients (IQ) ( P < 0.001), performance IQ ( P < 0.001), and verbal IQ ( P <0.02) with all nine irradiated patients scoring below their siblings. Also, educational quotients (EQ) of the irradiated patients were 12 to 17 points below the nonirradiated siblings with arithmetic EQ significantly decreased ( P < 0.01). Most severely affected were those children younger than 8 years at time of irradiation. No correlation was found with whole‐brain dose, or objective physical or neurologic findings.