Premium
Metastatic neuroblastoma arising in an ovarian teratoma with long‐term survival. Case report and review of the literature
Author(s) -
Block Margaret,
Gilbert Enid,
Davis Carleton
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840801)54:3<590::aid-cncr2820540334>3.0.co;2-3
Subject(s) - medicine , neuroblastoma , teratoma , radiation therapy , ovary , immature teratoma , presentation (obstetrics) , lymph , primary tumor , chemotherapy , germ cell tumors , metastasis , pathology , radiology , surgery , cancer , genetics , biology , cell culture
A case of neuroblastoma arising in an immature teratoma of the ovary in a 22‐year‐old woman is reported. Differentiation was grade 3 in the primary and metastases. Metastases to retroperitoneal, mediastinal, and supraclavicular lymph nodes and to bone were diagnosed 2 years after presentation of the primary tumor. Electron microscopic study demonstrated dense‐core granules of the neurosecretory elements. Treatment with combination chemotherapy followed by radiotherapy resulted in complete remission which continues to the time of this report, more than 4 years after diagnosis of the primary tumor. Prolonged survival of metastasizing grade 3 immature teratoma is distinctly uncommon. The literature pertaining to this unusual tumor and to neuroblastoma of adults is reviewed.