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Acute lymphoblastic leukemia supervening in a case of chronic lymphocytic leukemia after continuous 3‐year treatment with chlorambucil
Author(s) -
Eridani Sandro,
Parry Hugh,
Glass Ursula,
Greaves Mel
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840801)54:3<397::aid-cncr2820540305>3.0.co;2-p
Subject(s) - chlorambucil , clone (java method) , chronic lymphocytic leukemia , medicine , leukemia , population , karyotype , bone marrow , acute lymphocytic leukemia , trisomy , malignancy , immunology , cancer research , lymphoblastic leukemia , chromosome , pathology , chemotherapy , biology , genetics , cyclophosphamide , dna , environmental health , gene
A case is presented of a patient with classical chronic lymphatic leukemia (CLL) treated with continuous chlorambucil for 3 yars who presented with a picture of acute leukemia. The peripheral blood still showed a prevalence of mature lymphocytes with a few blast cells, whereas the bone marrow showed a predominant population of blast cells possessing a null acute lymphoblastic leukemia phenotype. Karyotype analysis showed a prevalent hyperdiploid clone of 67 to 68 chromosomes with endoreduplication and marker chromosomes. The coexistence of a CLL‐type population with the blastic, undifferentiated cell clone suggests a second malignancy superimposed on the previous leukemic process, and possibly brought about by the continuous chlorambucil treatment.