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Adenosplenomegaly and prognosis in uncomplicated and complicated chronic lymphocytic leukemia. A study of 362 cases
Author(s) -
Paolino Walter,
Infelise Vittorio,
Levis Alessandro,
Marmont Filippo,
Vitolo Umberto,
Paolino Franco,
Rossi Mario,
Jayme Augusto,
Remondino Mario
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840715)54:2<339::aid-cncr2820540227>3.0.co;2-h
Subject(s) - medicine , leukocytosis , anemia , chronic lymphocytic leukemia , gastroenterology , survival analysis , leukemia , surgery
Presence and size of lymph nodes and spleen, graded from 0 to +++, in 362 patients with CLL observed from diagnosis were evaluated. Statistical analysis showed a relationship with age, sex, anemia and thrombopenia, leukocytosis, and outlined two different groups: the one without organomegalies, with higher mean age (67 years), female prevalence, and better prognosis; the other with adenosplenomegaly graded ++/+++, with lower mean age (57 years), clear male prevalence, and worse prognosis. Survival results were statistically different only between groups 0/+ versus group ++/+++. Important chronic diseases were present at diagnosis in approximately 25% of the cases, with a severely reduced survival (median, 27 months), close to that of the cases with anemia and/or thrombopenia (22 months). Therefore it seems that in every prognostic grouping system, complicated cases should be taken into account and grouped with the anemic and/or the thrombopenic ones. The following prognostic groups are proposed: I: low risk: cases without or with adenomegaly and/or splenomegaly + (65% surviving at 100 months); II: intermediate risk: cases with adenomegaly and/or splenomegaly ++/+++ (median survival, 70 months); III: high risk: cases complicated by chronic diseases, or with anemia and/or thrombopenia (median survival, 25 months).