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Liver cell dysplasia and hepatitis B surface antigen in liver cirrhosis and hepatocellular carcinoma
Author(s) -
Akagi Go,
Furuya Keizo,
Kanamura Akira,
Chihara Tadao,
Otsuka Hisashi
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840715)54:2<315::aid-cncr2820540223>3.0.co;2-6
Subject(s) - hepatocellular carcinoma , cirrhosis , medicine , hbsag , dysplasia , liver cell , gastroenterology , pathology , hepatitis b , carcinoma , hepatitis , hepatitis b virus , immunology , virus
Liver tissues of 223 autopsy cases of cirrhosis and hepatocellular carcinoma were examined for liver cell dysplasia in relation to hepatitis B surface antigen (HBsAg) detected with orcein stain. Liver cell dysplasia was found in 94 cases (42.2%): 37 were from cases of cirrhosis only, and 53 were from cases of cirrhosis with hepatocellular carcinoma. There was a significant difference in the overall incidence of HBsAg in cases with and without dysplasia (70.2%:32.6%). A similar difference was found in all groups, i.e. , those with cirrhosis, cirrhosis with hepatocellular carcinoma, and hepatocellular carcinoma only, in which none of 11 cases of HBsAg negative had dysplasia. A good correlation was seen between the semiquantitative grade of dysplasia and the incidence of HBsAg. These findings suggest a close relationship of HBsAg with liver cell dysplasia.