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HeLa cell tumor response to 60 Co, Cs‐137, Cf‐252 radiations and cisplatin chemotherapy in nude mice
Author(s) -
Maruyama Yosh,
Feola Jose M.,
Beach J. Lawrence
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840715)54:2<247::aid-cncr2820540211>3.0.co;2-7
Subject(s) - hela , cisplatin , nuclear medicine , irradiation , medicine , cancer research , cell , chemotherapy , radiochemistry , microbiology and biotechnology , chemistry , biology , physics , biochemistry , nuclear physics
HeLa cells were implanted into athymic nude mice from tissue culture and solid tumors established (HeLa cell tumor or HCT). Large cell numbers of 1 x 10 7 were required to obtain consistent and progressive growth, and tumor growth followed a Gompertzian mode. Irradiation studies were carried out using acute Cobalt‐60 ( 60 Co), low‐dose‐rate (LDR) Cs‐137 and LDR Cf‐252. Cf‐252, a neutron‐emitting radioisotope, produced an immediate tumor shrinkage and regression response after a dose of 279 cGy. Acute 60 Co or LDR Cs‐137 irradiation with 1000 cGy had little effect on the HCT. After a dose of 2000 cGy of 60 Co radiation tumor shrinkage followed a latent period of approximately 5 days. Cisplatin had no effect on the HCT in nude mice in stationary or late exponential growth.