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Hodgkin's disease in children. Results of therapy in a mixed group of 178 clinical and pathologically staged patients over 13 years
Author(s) -
BayleWeisgerber Chantal,
Lemercier Noëlle,
Teillet François,
Asselain Bernard,
Gout Michèle,
Schweisguth Odile
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840715)54:2<215::aid-cncr2820540207>3.0.co;2-#
Subject(s) - medicine , disease , pediatrics , surgery
One hundred seventy‐eight previously untreated children with biopsy‐proven Hodgkin's disease of clinical Stages I and II were treated and followed between 1965 and 1978. Staging laparotomy was performed in 30 patients. Ninety‐four percent of the patients obtained a complete remission; 24 patients have died. The actuarial survival rate for all patients was 90% at 5 years, and 81% at 10 years. The disease‐free survival rate was 69% at 5 years, and 65% at 10 years. When nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP) chemotherapy was added to either extended field or involved field irradiation, the relapse rate was significantly decreased as compared with the protocols without MOPP and prophylactic para‐aortic irradiation. The authors believe that surgical staging may not be necessary as splenic involvement may be treated in some patients by MOPP chemotherapy alone or in association with splenic para‐aortic radiotherapy. However, the side effects of MOPP need further study by other chemotherapy programs.