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Salvage therapy of aggressive non‐Hodgkin's lymphoma with a combination of vinblastine, bleomycin, and cisplatin
Author(s) -
Corder Michael P.,
Clamon Gerald H.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840715)54:2<202::aid-cncr2820540204>3.0.co;2-i
Subject(s) - medicine , vinblastine , bleomycin , vomiting , nausea , chemotherapy , cisplatin , gastroenterology , lymphoma , surgery , sepsis , salvage therapy , anemia , combination chemotherapy , cyclophosphamide
Thirteen patients with aggressive histologic types of non‐Hodgkin's lymphoma had failed to respond or relapsed after intensive polychemotherapy of curative intent. They were treated with a combination of vinblastine, bleomycin, and cisplatin. All were Stage III or IV, and eight had systemic symptoms. There were five objective partial remissions, and no complete remissions. The Kaplan‐Meier 50% survival estimate is 5 months from initiation of the salvage chemotherapy. Seven of 13 patients had grade II nausea and vomiting, and 7 had nadir platelet counts less than 70,000/mm 3 . All had significant anemia. There were two episodes of sepsis, and two patients had pulmonary and nephrotoxicity. The program is not effective in this situation, and is quite toxic.