Premium
The use of scalp hypothermia in the prevention of doxorubicin‐induced hair loss
Author(s) -
Satterwhite Barbara,
Zimm Solomon
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840701)54:1<34::aid-cncr2820540109>3.0.co;2-w
Subject(s) - scalp , medicine , hypothermia , doxorubicin , hair loss , chemotherapy , randomized controlled trial , anesthesia , surgery , hair growth , dermatology , physiology
A randomized clinical trial was performed to determine the effectiveness of scalp hypothermia in the prevention of hair loss associated with doxorubicin. Twenty‐six patients were randomized to receive scalp hypothermia or chemotherapy alone. Data were analyzed on 25 patients: 12 in the treatment group and 13 in the control group. There was acceptable hair preservation in 75% of the patients who received the scalp hypothermia; only 8% of the patients in the control group had acceptable hair preservation (P = 0.0009). The data were further broken down into patients receiving low‐dose doxorubicin and high‐dose doxorubicin. Side effects were minimal. The results support the use of scalp hypothermia in reducing doxorubicin‐induced alopecia.