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Rate of growth of intraabdominal metastases from colorectal cancer
Author(s) -
Havelaar Ian J.,
Sugarbaker Paul H.,
Vermess Michael,
Miller Donald L.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840701)54:1<163::aid-cncr2820540131>3.0.co;2-v
Subject(s) - medicine , colorectal cancer , lymph node , doubling time , chemotherapy , radiology , cancer , oncology , disease , in vitro , biochemistry , chemistry
Monitoring the progression or regression of intraabdominal metastatic disease is required for knowledgeable management of chemotherapeutic regimens designed to treat metastases. Computerized tomography (CT) and CT with EOE‐13, a liver contrast agent, allowed precise measurement of metastatic disease. The tumor doubling time of colorectal metastases in four patients was determined from serial CT scans of individual patients. Tumor doubling times of untreated patients varied from 50 to 95 days, and were in the same range for hepatic, lymph node, or intraperitoneal metastatic disease. These data may indicate that metastatic disease of colorectal cancer progresses at a faster rate in the peritoneal cavity than is reported for colorectal cancer metastatic to the lungs. The response to chemotherapy or progression of disease was also determined in treated patients. High resolution CT scanning with EOE‐13 allowed calculation of tumor doubling times, and therefore more precise management of cancer patients with metastases.