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Unusual clinical courses of adult T‐cell leukemia in siblings
Author(s) -
Kawano Fumio,
Tsuda Hiroyukl,
Yamaguchi Kazunari,
Nishimura Hiromichi,
Sanada Isao,
Matsuzaki Hiromitsu,
Ishii Masao,
Takatsuki Kiyoshi
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840701)54:1<131::aid-cncr2820540126>3.0.co;2-q
Subject(s) - medicine , sister , brother , leukemia , disease , stage (stratigraphy) , antibody , chemotherapy , t cell leukemia , antigen , immunology , pediatrics , paleontology , sociology , anthropology , biology
Two siblings who developed adult T‐cell leukemia (ATL) with unusual clinical courses are presented. The brother showed spontaneous remissions at the beginning stage of the disease of 6 years' duration, and the sister remains free of complaints for 6 years without chemotherapy. The patients and 2 of 12 healthy members of their family examined had serum antibodies against ATL‐associated antigens (ATLA). The expression of ATLA was observed in the cultured lymphocytes from the patients and one of the family members.