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Adenocarcinoma in situ and invasive adenocarcinoma of the uterine cervix. An immunohistologic study with antibodies specific for several epithelial markers
Author(s) -
Hurlimann Jean,
Gloor Etienne
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840701)54:1<103::aid-cncr2820540122>3.0.co;2-z
Subject(s) - carcinoembryonic antigen , keratin , pathology , adenocarcinoma , antigen , antibody , medicine , immunohistochemistry , cervix , cytokeratin , uterine cervix , carcinoma , cancer , immunology
The distribution of carcinoembryonic antigen (CEA), secretory component (SC), fat globule membrane antigens (FGMA), and keratin was determined immunohistochemically in 22 invasive adenocarcinomas of various types and in 9 adenocarcinomas in situ of the uterine cervix. In the invasive adenocarcinomas 77% were positive for CEA, 47% for SC, 89% for keratin, and 77% for FGMA. In adenocarcinomas in situ 67% were positive for CEA, 11% for SC, and 44% for keratin. The location of the markers was variable in the cells, and the cells in a tumor were irregularly positive. For a given histologic type there were several phenotypes. No correlation was found between histologic types of invasive adenocarcinomas and the various phenotypes. It remains to be shown whether a particular phenotype has a particular biological behavior. The detection in the serum of the markers shown in histologic preparations could be useful in the postsurgical monitoring.