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Patterns of bone marrow involvement with small cell lung cancer
Author(s) -
Clamon Gerald H.,
Edwards William R.,
Hamous James E.,
Scupham Richard K.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840701)54:1<100::aid-cncr2820540121>3.0.co;2-a
Subject(s) - medicine , bone marrow , pathology , lung cancer , lung , cancer , oncology
The extent of tumor involvement, necrosis, reticulin, and megakaryocytosis were assessed in 25 patients with small cell lung cancer in their bone marrow at diagnosis. The pattern of marrow involvement was compared with clinical outcome and tolerance of therapy. Any marrow involvement, no matter how minor, is a poor prognostic factor. Neither more extensive involvement, nor greater marrow fibrosis significantly worsened the prognosis.