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Estrone sulphate plasma levels in postmenopausal women with and without endometrial cancer
Author(s) -
Jasonni Valerio M.,
Bulletti Carlo,
Franceschetti Franca,
Bonavia Micaela,
Bolelli Gianfranco,
Ciotti Patrizia,
Flamigni Carlo
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840615)53:12<2698::aid-cncr2820531223>3.0.co;2-o
Subject(s) - estrone , endometrial cancer , medicine , estrogen , menopause , cancer , postmenopausal women , endocrinology , estrone sulfate , plasma levels , gynecology
Plasma estrone sulphate (E 1 S) and estrone (E 1 ) concentrations were determined in healthy postmenopausal women and in postmenopausal women with endometrial cancer, matched for body weight, age, and years since menopause. E 1 S levels (mean ± SD) were significantly higher ( P < 0.05) in cancer patients with normal weight (511 ± 200 pg/ml) than in control subjects (303 ± 99 pg/ml). E 1 S levels were also higher in obese cancer patients (691 ± 328 pg/ml) than in obese control subjects (610 ± 139 pg/ml). Both cancer groups showed similar plasma E 1 levels as compared with their respective controls. The E 1 S/E 1 ratio was higher in both groups of cancer patients than in control subjects. These data suggest that estrogen conjugates should be taken into account during studies on estrogen balance and endometrial cancer.