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Pancreatic polypeptide‐producing tumors report on two cases
Author(s) -
Nobin Anders,
Ingemansson Stig,
Berg Margareta,
Ericsson Mats,
Olsson Erik,
Sundler Frank
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840615)53:12<2688::aid-cncr2820531221>3.0.co;2-v
Subject(s) - medicine , gastrin , pancreatic polypeptide , endocrine system , serotonin , pancreatic tumor , pancreas , enteroendocrine cell , pathology , multiple endocrine neoplasia , pancreatic cancer , gastroenterology , endocrinology , cancer , secretion , hormone , biology , receptor , biochemistry , glucagon , gene
Histochemical, chemical and clinical features of two malignant endocrine pancreatic tumors were studied. Both tumors contained pancreatic polypeptide (PP)‐immunoreactivity in the majority of tumor cells. in addition, one tumor contained a few scattered serotonin‐fluorescent cells and the other scattered gastrin‐immunoreactive cells. Pancreatic polypeptide hypersecretion was established from both tumors. Serotonin was produced by one tumor and gastrin was secreted by the other. No PP‐associated endocrine symptoms were present, whereas the hypergastrinemia may have caused a bleeding duodenal ulcer in one patient. Although both tumors were highly malignant the clinical courses in the two patients were very different; one patient died within a few months whereas the other is alive 2 years after the diagnosis.