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Cytophotometric dna analysis of mucosal and submucosal carcinoma of the esophagus
Author(s) -
Sugimachi Keizo,
Okamura Takeshi,
Matsuura Hiroshi,
Ide Hiroko,
Endo Mitsuo,
Inokuchi Kiyoshi
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840615)53:12<2683::aid-cncr2820531220>3.0.co;2-c
Subject(s) - esophagus , carcinoma , dna , nuclear dna , medicine , esophageal cancer , pathology , gastroenterology , cancer , biology , gene , genetics , mitochondrial dna
Cell nuclear deoxyribonucleic acid (DNA) content was microspectrophotometrically determined in 35 cases of mucosal and submucosal carcinoma of the esophagus. DNA distribution pattern was classified into types I, II, III, and IV, according to the degree of dispersion on the DNA histogram, in the order of wider distribution. Patients with types I and II (relatively regular in DNA distribution) had an uneventful postoperative course and no recurrence, whereas 3 of 15 (20%), and 5 of 9 (55.6%) with type III and type IV, respectively (widely scattered DNA distribution), died following a recurrence. Cytophotometric DNA analysis of the cancer cells reflected well the outcome in patients with esophageal carcinoma. These results suggest the potential usefulness of cytophotometric DNA analysis for assessing the prognosis, even in the early stage of esophageal carcinoma.