Premium
Extranodal lymphoma terminating in acute leukemia associated with igd monoclonal gammopathy a case report
Author(s) -
Inui Jiro,
Nakamine Hirokazu,
Nishihara Toru,
Takenaka Toru,
Iwahashi Yoshiaki
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840601)53:11<2487::aid-cncr2820531121>3.0.co;2-e
Subject(s) - immunoglobulin d , medicine , pathology , lymphoma , bone marrow , gammopathy , monoclonal , monoclonal gammopathy of undetermined significance , monoclonal antibody , immunology , b cell , antibody
A case of malignant lymphoma associated with IgD monoclonal gammopathy is described. Orbital and testicular tumors were observed, while peripheral lymphadenopathy was absent. Neoplastic lymphoid cells appeared in peripheral blood, bone marrow, and pleural effusion with progression of the disease. Analysis of the serum suggested “unreactive” light chain determinants in monoclonal protein. in immunohistochemical studies and in vitro experiments, it was confirmed that IgD monoclonal gammopathy was directly related to the neoplastic cells. These unusual findings suggest that neoplastic changes such as neoplasms of other B‐cell systems may occur at various stages in the differentiation and maturation of IgD‐forming B‐cell lineage.