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Osteogenic sarcoma producing human chorionic gonadotrophin: Case report with immunohistochemical studies
Author(s) -
Kalra Jagmohan K.,
Mir Rabia,
Kahn Leonard B.,
Wessely Zelma,
Shah Arvind B.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840515)53:10<2125::aid-cncr2820531022>3.0.co;2-u
Subject(s) - immunohistochemistry , medicine , sarcoma , curettage , chorionic villi , pregnancy , osteosarcoma , pathology , gynecology , fetus , placenta , biology , genetics
Abstract An osteogenic sarcoma occurring in a 22‐year‐old woman was found to be associated with production of a large amount of beta human chorionic gonadotrophin (B‐hCG). Pregnancy was excluded on the basis of a normal ultrasonogram and a proliferative type endometrium obtained by curettage. A homogenate of the tumor was strongly positive for B‐hCG while immunohistochemical staining of the tumor cells was strongly positive for B‐hCG and negative for pregnancy associated glycoprotein. These results indicate ectopic production of hCG by the osteosarcoma.