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Multiple visceral and cutaneous granular cell tumors. Ultrastructural and immunocytochemical evidence of Schwann cell origin
Author(s) -
Seo In Sook,
Azzarelli Biagio,
Warner Thomas F.,
Goheen Michael P.,
Senteney Gary E.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840515)53:10<2104::aid-cncr2820531019>3.0.co;2-f
Subject(s) - pathology , granular cell , granular cell tumor , ultrastructure , schwann cell , stomach , medicine , cell , immunohistochemistry , biology , central nervous system , gastroenterology , genetics , endocrinology
Granular cell tumor of the stomach is rare and may occur in association with similar tumors in the skin. Two such tumors were found in association with cutaneous granular cell tumors in two black females. Infiltrating carcinoma of the stomach was suspected at surgery in one case. All of the lesions were typical granular cell tumors on light microscopic examination. Ultrastructural examination showed clusters of tumor cells that were surrounded by basal laminae and axonal structures were present among the tumor cells. S‐100 protein immunoreactivity was also demonstrated in the tumor cells. These findings suggest a Schwannian origin for visceral granular cell tumors.