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An analysis of neuroblastoma at a single institution
Author(s) -
Thomas Patrick R. M.,
Lee Jeannette Y.,
Fineberg Barbara B.,
Razek Aly A.,
Perez Carlos A.,
Land Vita J.,
Vietti Teresa J.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840515)53:10<2079::aid-cncr2820531013>3.0.co;2-e
Subject(s) - ganglioneuroblastoma , medicine , neuroblastoma , logistic regression , stage (stratigraphy) , prognostic variable , nomogram , disease , histology , oncology , ganglioneuroma , overall survival , paleontology , genetics , biology , cell culture
Between 1949 and 1978, 119 children with the diagnosis of neuroblastoma or ganglioneuroblastoma were treated at the Washington University Medical Center. Of these, 50 (41%) were alive and disease‐free 3 or more years after diagnosis. Important prognostic variables included stage of tumor (Evans staging), histology, age at diagnosis, and site of primary tumor. A stepwise logistic regression analysis of these data has shown that, in order of significance, stage, histology and age at diagnosis are independent prognostic variables. Sex of the patient and nodal status at diagnosis (where known) were not significant prognostic variables. No effects of individual treatment modalities could be detected. This study confirms the overwhelming influence of factors unrelated to treatment in determining the prognosis of neuroblastoma.